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pizza meatloaf recipe

Pizza Meatloaf

Pizza meatloaf is two comfort foods in one! This turkey meatloaf recipe is low fat, low carb, gluten-free, and delicious! It's everything you love about Friday night pizza but transformed into a healthy weeknight dinner! 
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Course: dinner, dinner recipe
Cuisine: American
Keyword: pizza meatloaf, pizza meatloaf recipe
Prep Time: 25 minutes
Cook Time: 1 hour
Total Time: 1 hour 25 minutes
Servings: 8 people
Calories: 357kcal


  • Large skillet
  • Large Mixing Bowls
  • Large rimmed baking sheet or loaf pan


  • 1 medium onion chopped into small pieces
  • 1 10-ounce package sliced white mushrooms
  • 1 tablespoon olive oil
  • 2 slices wheat bread use gluten-free if needed
  • 2 large eggs
  • 3-4 tablespoons milk
  • 2 lbs 93/7 ground turkey
  • 1 cup homemade pizza sauce divided
  • 1 cup turkey pepperoni chopped (before chopping save 6-8 slices for top of the meatloaf)
  • 1 1/2 cups shredded mozzarella cheese divided
  • 1/4 cup grated romano cheese
  • 2 teaspoons Italian seasoning
  • 2 teaspoons garlic powder
  • 2 teaspoons onion powder
  • 1 teaspoon salt
  • 1 teaspoon ground black pepper
  • 2 tablespoons Worcestershire sauce


  • Start with preheating the oven to 350 degrees.
  • While the oven is heating, work on the onion and mushrooms. If you're using other vegetables, this is the time you'll cook those too. Heat the olive oil in a large skillet over medium-high heat. Add the onions and mushrooms and sauté until the onions are translucent and the mushrooms are soft. Season with salt and pepper. Drain extra liquid from the vegetables if needed and then place into a small bowl and set aside to cool.
  • While the vegetables cool, mix the meatloaf.
  • Combine the bread and milk in a large bowl until it forms a paste. Then add the eggs to the paste and mix until combined.
  • To the mixing bowl, add in the ground turkey, 1/2 cup of the pizza sauce, pepperoni (make sure to save 6- 8 slices for the top of the meatloaf), 1 cup mozzarella cheese, Italian seasoning, garlic powder, onion powder, salt, Worcestershire sauce, and romano cheese. Lightly mix all the ingredients. 
  • Add vegetables and mix again until evenly distributed in the meatloaf mixture.
  • Pour the meatloaf mixture onto a large rimmed baking sheet sprayed with cooking spray. You can also use a meatloaf pan.
  • Then spread 1/2 cup of the pizza sauce over the top.
  • Place it into the oven and cook for 1 hour. The internal temperature should be 165 degrees when it's done cooking.
  • Remove the meatloaf from the oven and set the oven to broil.
  • Sprinkle the rest of the mozzarella cheese on the meatloaf, and then place 6-8 slices of pepperoni over the cheese. 
  • Broil for 2-3 minutes or until the cheese is melted and the pepperoni gets crisp. Keep your eye on the meatloaf because it can burn quickly.
  • Remove from the oven and sit for about 3-5 minutes to seal in all juices.
  • Cut into eight slices and serve hot.


Storage tips
For the week.
Cook the pizza meatloaf completely, slice it into portions, place it into a glass container, and store it in the refrigerator for up to 4 days. I like to make individual dinners by placing a slice of meatloaf, veggie, and grain or potato into an airtight container. 
To reheat, place the microwave-safe container into the microwave and heat on high for 2-3 minutes or until hot.
You can also assemble the meatloaf and refrigerate it for up to 2 days. Continue with the meatloaf recipe on the night you plan to cook it. 
To freeze.
Meatloaf can be frozen, cooked, or raw. Check the how-to freeze meatloaf tutorial I put together for all of my tips.


Serving: 1g | Calories: 357kcal | Carbohydrates: 26g | Protein: 34g | Fat: 20g | Saturated Fat: 6g | Cholesterol: 158mg | Sodium: 875mg | Fiber: 1g | Sugar: 4g