Mix the garlic powder, onion powder, sugar, chipotle chili powder, cumin, salt, and pepper into a small bowl. Set aside.
Place the pork butt onto a cutting board. If needed, trim off any excess fat from the top and sides.
Pour the orange juice into the bottom of the slow cooker insert
Place the pork butt into the slow cooker.
Cover and cook on low for 8-10 hours. Or on high for 5-6 hours. When the pork is pull-apart tender it's done cooking.
Remove the pork from the slow cooker and place it into a large bowl. Using two forks or claws, shred the pork. Spoon extra liquid from the slow cooker for added moisture
Use in your favorite pork recipes.